Expert systems for analysis of biomedical information in the diagnosis of acute leukemia
Jinqiong Li, Sergii Pavlov, Oleksii StakhovThis study contributes to further improvement of knowledge and accuracy of diagnostic methods. It also plays an important role in the diagnosis and treatment of acute leukemia today. The application of various technologies, exchange of experience and ideas have significant achievements that will have a revolutionary effect in patient care and improve diagnostic accuracy. The most significant contribution is the development and implementation of technologies, especially artificial intelligence (AI) or machine learning. The study illustrates how AI-based models can help evaluate and interpret biomedical data, providing more accurate diagnoses and facilitating decision-making. Trained on large databases, such models show promise in identifying subtle patterns indicative of different subtypes of leukemia, which could lead to more precise and tailored treatments. The study of new biomarkers, the use of advanced imaging techniques, and the use of new technologies such as blockchain for data security represent promising avenues for progress. However, addressing challenges such as regulatory compliance, ethical considerations, and the complexity of identifying appropriate drug candidates remains key to responsible development
References
[1] Abdeldaim, A.M., Sahlol, A.T., Elhoseny, M., & Hassanien, A.E. (2018). Computer-aided acute lymphoblastic leukemia diagnosis system based on image analysis. In Advances in soft computing and machine learning in image processing (Vol. 730, pp. 131-147). Cham: Springer. doi: 10.1007/978-3-319-63754-9_7.
[2] Ahmed, I.A., Senan, E.M., Shatnawi, H.S.A., Alkhraisha, Z.M., & Al-Azzam, M.M.A. (2023). Hybrid techniques for the diagnosis of acute lymphoblastic leukemia based on fusion of CNN features. Diagnostics, 13(6), article number 1026. doi: 10.3390/diagnostics13061026.
[3] Ansari, S., Navin, A.H., Sangar, A.B., Gharamaleki, J.V., & Danishvar, S. (2023). A customized efficient deep learning model for the diagnosis of acute leukemia cells based on lymphocyte and monocyte images. Electronics, 12(2), article number 322. doi: 10.3390/electronics12020322.
[4] Arber, D.A. et al. (2017). Initial diagnostic workup of acute leukemia: Guideline from the College of American Pathologists and the American Society of Hematology. Archives of Pathology & Laboratory Medicine, 141(10), 1342-1393. doi: 10.5858/arpa.2016-0504-cp.
[5] Pavlov, S.V., Saldan, Y.R., Karas, O.V., & Tymchyk, S.V. (2023). Analysis of methods and systems for diagnosing diabetic retinopathy. Optical-electronic Information and Energy Technologies, 46(2), 135-141.
[6] Jincun, L., & Pavlov, S. (2023). Expert bioinformation system for diagnosis of forms of acute leukemia based on analysis of biomedical information. Information Technology and Computer Engineering, 20(3), 84-93. doi: 10.31649/1999-9941-2023-58-3-84-93.
[7] Wójcik, W., Pavlov, S., & Kalimoldayev, M. (2019). Information technology in medical diagnostics II. London: Taylor & Francis Group, CRC Press. doi: 10.1201/9780429057618.
[8] Chen, K.X. (2020). Academician kai-xian chen talks about the development of traditional chinese medicine and global medicine. World Journal of Traditional Chinese Medicine, 6(1), 1-11. doi: 10.4103/wjtcm.wjtcm_30_19.
[9] Chiaretti, S., Zini, G., & Bassan, R. (2014). Diagnosis and subclassification of acute lymphoblastic leukemia. Mediterranean Journal of Hematology and Infectious Diseases, 6(1), article number e2014073. doi: 10.4084/mjhid.2014.073.
[10] Cicconi, L., & Lo-Coco, F. (2016). Current management of newly diagnosed acute promyelocytic leukemia. Annals of Oncology, 27(8), 1474-1481. doi: 10.1093/annonc/mdw171.
[11] Ahsan, S., Farooq, A., Shahbaz, M., & Arshad, M.J. (2012). 1 scaling technique for web based management systems in bioinformatics. Life Science Journal, 9(3), 1-5.
[12] Davis, A.S., Viera, A.J., & Mead, M D. (2014). Leukemia: an overview for primary care. American Family Physician, 89(9), 731-738.
[13] Estey, E.H. (2012). Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management. American Journal of Hematology, 87(1), 89-99. doi: 10.1002/ajh.22246.
[14] Grimwade, L.F., Fuller, K.A., & Erber, W.N. (2017). Applications of imaging flow cytometry in the diagnostic assessment of acute leukaemia. Methods, 112, 39-45. doi:.1016/j.ymeth.2016.06.023.
[15] Haferlach, T. et al. (2010). Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: Report from the International microarray innovations in leukemia study group. Journal of Clinical Oncology, 28(15), 2529-2537. doi: 10.1200/jco.2009.23.4732.
[16] Harrison, C.J., & Johansson, B. (2015). Acute lymphoblastic leukemia. In S. Heim & F. Mitelman (Eds.), Cancer cytogenetics: Chromosomal and molecular genetic aberrations of tumor cells (pp. 198-251). Hoboken: John Wiley & Sons. doi: 10.1002/9781118795569.ch10.